Polynucleotides vs Profhilo: Key Differences & Benefits

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Polynucleotides vs Profhilo: Key Differences & Benefits 6



Polynucleotides vs Profhilo: The new frontier of skin regeneration


As skin rejuvenation continues to evolve, two standout treatments are capturing the attention of skincare enthusiasts and beauty editors alike: Profhilo and Polynucleotides. Both treatments promise to revive tired, ageing skin and deliver a youthful glow, yet they work in distinct ways to achieve these results. If you’re curious about which treatment is right for you—or you’re a journalist seeking the latest insights into beauty innovations—read on for a comprehensive look at these cutting-edge treatments.


What are Polynucleotides?

Polynucleotides are the newest frontier in regenerative skin treatments. Unlike hyaluronic acid, polynucleotides work by introducing DNA fragments into the skin that encourage cell repair, regeneration, and collagen production. This makes it a powerful tool for healing and rejuvenation at a cellular level, perfect for those seeking a more intensive, deep-reaching treatment for skin renewal.

How do Polynucleotides Work

Polynucleotides are injected into the skin where they activate multiple biological processes:

Tissue Repair: Polynucleotides initiate cellular repair, promoting healthy cell turnover and the regeneration of damaged skin.
Collagen and Elastin Stimulation: By stimulating collagen and elastin production, they increase skin firmness and elasticity.
Anti-Inflammatory Properties: Polynucleotides also reduce inflammation, making them ideal for sensitive or damaged skin.

young woman getting prp treatment high angle

Benefits of Polynucleotides

Regenerative Effect: Repairs damaged skin cells and rejuvenates at a deeper level.
Improved Elasticity and Firmness: Provides a lifting effect by enhancing skin structure.
Brightens Skin Tone: Creates a radiant glow by evening out pigmentation and reducing sun damage.
Effective on Scarring and Pigmentation: Polynucleotides are highly effective for healing scars, acne damage, and hyperpigmentation.
Supports Healing Post-Treatment: Often used in combination with lasers and peels to speed up healing and reduce inflammation.

Who are Polynucleotides Best For?

Polynucleotides are suited for individuals with specific skin concerns like acne scarring, pigmentation, and visible signs of ageing such as sagging or dull skin. They are also excellent for those seeking long-term repair and rejuvenation and are ideal

What is Profhilo?

Profhilo is a revolutionary injectable treatment formulated with one of the highest concentrations of pure hyaluronic acid available. But unlike traditional dermal fillers, which are designed to add volume, Profhilo spreads under the skin, deeply hydrating and stimulating the natural production of collagen and elastin for a softer, more youthful look. It’s become incredibly popular among those who want to improve skin quality without altering facial contours.

How Profhilo Works

Profhilo’s unique approach is sometimes referred to as “bio-remodelling.” Here’s how it works:

Injection Points: Profhilo is injected into precise areas just beneath the skin’s surface, usually requiring two treatments four weeks apart.
Spreading Mechanism: Once injected, it spreads throughout the dermal layers, delivering hydration and stimulating skin cell regeneration.
Collagen and Elastin Boost: The treatment triggers collagen and elastin production, essential for skin strength, structure, and elasticity.Benefits of Profhilo

Hydration: Profhilo is perfect for deeply hydrating the skin, especially for those dealing with dryness or dullness.
Elasticity and Firmness: Increases elasticity, helping to firm the skin.
Improved Skin Quality: The skin appears plumper, with a more even tone and texture.
Minimal Downtime: Quick and relatively painless, Profhilo is great for those seeking a no-downtime treatment.

Who is Profhilo Best For?

Profhilo is ideal for individuals experiencing early signs of ageing, fine lines, and loss of firmness. It’s a subtle, natural-looking treatment for those who want their skin to look refreshed without the more volumising effect of traditional fillers.

Polynucleotides vs Profhilo: Which One Should You Choose?

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Polynucleotides vs Profhilo: Key Differences & Benefits 7

Choosing between Profhilo and Polynucleotides comes down to your skin’s needs and your aesthetic goals. Here’s a side-by-side comparison:

Feature Profhilo Polynucleotides
Main Ingredient Hyaluronic acid DNA fragments (Polynucleotides)
Primary Benefit Hydration, elasticity Deep regeneration, repair
Best for Fine lines, dryness, mild ageing signs Scarring, pigmentation, advanced signs of ageing
Key Benefits Hydrates, plumps, firms Repairs damaged cells, improves elasticity, heals
Treatment Frequency Typically two sessions over four weeks Varies based on skin needs
Downtime Minimal Minimal


Combining Profhilo and Polynucleotides

For individuals looking to maximise skin rejuvenation, combining Profhilo and Polynucleotides can be a game-changer. Starting with Polynucleotides to repair and regenerate the skin, followed by Profhilo to boost hydration and elasticity, offers a layered approach to achieve the best results in skin quality, texture, and firmness.

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Whether you choose Profhilo or Polynucleotides, both treatments represent the forefront of aesthetic medicine, offering powerful skin rejuvenation benefits without the need for invasive surgery. From hydration and firmness to repair and regeneration, these treatments offer distinct advantages and can even be combined for an optimal skincare journey.


FAQ’s

How long do the results of each treatment last?

Profhilo: Results generally last up to six months, depending on individual factors like age and skin quality.

Can these treatments be combined with other aesthetic procedures?

Yes, both Profhilo and Polynucleotides complement treatments like laser therapy, microneedling, and peels, enhancing overall results.

What are the possible side effects?

Both treatments have minimal downtime and may cause minor redness or swelling that usually resolves within a few hours to a couple of days.

In Summary

 

    • Choose Profhilo if you want deeply hydrated, firmer skin with improved elasticity and a subtle, refreshed appearance.

    • Choose Polynucleotides if you’re dealing with scarring, pigmentation, or need intense rejuvenation, as they help rebuild skin from within, leading to smoother, healthier skin.

Final Thoughts

Whether you choose Profhilo or Polynucleotides, both treatments represent the forefront of aesthetic medicine, offering powerful skin rejuvenation benefits without the need for invasive surgery. From hydration and firmness to repair and regeneration, these treatments offer distinct advantages and can even be combined for an optimal skincare journey.

Thinking about trying Profhilo or Polynucleotides? Book a consultation to find out which treatment is best suited to your skin needs and goals!

 

Avatar of Natasha Borciani
Natasha Borciani – Clinical Director, Borciani London Natasha Borciani is a highly experienced aesthetic practitioner with over a decade devoted to scar reduction and skin repair, with particular expertise in self-harm scar treatment. After an early career in the tech industry, she brought an analytical, data-driven mindset into aesthetics, graduating from the London School of Beauty Therapy (2010) and specialising in medical tattooing for scar camouflage and areola reconstruction. At her central London clinic, Natasha combines compassion with evidence-led care. She integrates CO₂ laser resurfacing, vascular lasers, IPL photorejuvenation, advanced chemical peels (TCA), microneedling, and non-dermal-filler injectables (PRF/PRP, polynucleotides, exosomes), alongside medical & cosmetic micropigmentation (permanent eyeliner, lips, hair-stroke brows, scalp micropigmentation). Natasha has extensive experience working with skin of colour and tailors protocols to different skin tones and scar behaviours. Her clinic runs a subsidised programme for self-harm scars to improve access to care in a private, respectful environment. She is a member of the British Medical Laser Association (BMLA), holds VTCT Levels 4, and is SPCP and BABTAC affiliated. Natasha is double-certified by Dawn Cragg in micropigmentation and tattoo removal and has trained with the top academies globally. Her work has been published in Aesthetic Medicine Magazine on hair-loss treatment approaches and featured in publications such as Elle Magazine and Harper’s Bazaar.

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